Irene Cózar-Castellano Selected Research

Insulysin (Insulin-Degrading Enzyme)

1/2022	Insulin-degrading enzyme ablation in mouse pancreatic alpha cells triggers cell proliferation, hyperplasia and glucagon secretion dysregulation.
1/2021	Modulation of Insulin Sensitivity by Insulin-Degrading Enzyme.
1/2021	Effects of Fasting and Feeding on Transcriptional and Posttranscriptional Regulation of Insulin-Degrading Enzyme in Mice.
11/2019	Pancreatic β-cell-specific deletion of insulin-degrading enzyme leads to dysregulated insulin secretion and β-cell functional immaturity.
11/2018	Liver-specific ablation of insulin-degrading enzyme causes hepatic insulin resistance and glucose intolerance, without affecting insulin clearance in mice.

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Irene Cózar-Castellano Research Topics

Disease

10	Insulin Resistance 01/2021 - 06/2012
4	Obesity 12/2020 - 09/2017
3	Type 2 Diabetes Mellitus (MODY) 01/2022 - 11/2019
3	Glucose Intolerance 11/2018 - 06/2012
2	Hyperinsulinism (Hyperinsulinemia) 12/2020 - 12/2011
2	Body Weight (Weight, Body) 06/2012 - 12/2011
2	Multiple Myeloma 01/2012 - 01/2012
1	Hyperplasia 01/2022
1	Gliosis 07/2020
1	Neuroinflammatory Diseases 07/2020
1	Inflammation (Inflammations) 07/2020
1	Metabolic Diseases (Metabolic Disease) 12/2019
1	Insulinoma 07/2019
1	Gestational Diabetes (Gestational Diabetes Mellitus) 07/2015
1	Pregnancy Complications 07/2013
1	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 01/2013
1	Dyslipidemias (Dyslipidemia) 12/2011
1	Hypertriglyceridemia 12/2011

Drug/Important Bio-Agent (IBA)

7	Insulin (Novolin)FDA Link 01/2021 - 12/2011
7	Glucose (Dextrose)FDA LinkGeneric 12/2020 - 06/2012
5	Insulysin (Insulin-Degrading Enzyme)IBA 01/2022 - 11/2018
4	Fatty Acids (Saturated Fatty Acids)IBA 09/2017 - 01/2012
2	Blood Glucose (Blood Sugar)IBA 01/2021 - 01/2020
2	leptolideIBA 07/2020 - 09/2017
2	Triglycerides (Triacylglycerol)IBA 07/2013 - 12/2011
1	Glucagon (Glukagon)FDA Link 01/2022
1	Metalloproteases (Metalloproteinases)IBA 01/2021
1	Proteins (Proteins, Gene)FDA Link 01/2021
1	Biomarkers (Surrogate Marker)IBA 01/2021
1	Insulin ReceptorIBA 12/2020
1	Glucose Transporter Type 2IBA 12/2020
1	Hormones (Hormone)IBA 01/2020
1	FructoseIBA 12/2019
1	SugarsIBA 12/2019
1	Potassium IonophoresIBA 07/2019
1	cereulideIBA 07/2019
1	PalmitatesIBA 09/2017
1	Streptozocin (Streptozotocin)FDA Link 01/2015
1	Carnitine O-Palmitoyltransferase (Carnitine Palmitoyltransferase II)IBA 07/2013
1	2- cyclohexylidenhydrazo- 4- phenyl- thiazoleIBA 07/2013
1	Leptin ReceptorsIBA 06/2012
1	oxidized low density lipoproteinIBA 01/2012
1	LDL CholesterolIBA 01/2012
1	Apolipoproteins D (Apo D)IBA 12/2011

Therapy/Procedure

2	Therapeutics 01/2021 - 01/2013
1	Intraperitoneal Injections 12/2020
1	Cesarean Section (Caesarean Section) 07/2015